Anesthesia in Experimental Stroke Research
نویسندگان
چکیده
منابع مشابه
Recommendations guide for experimental animal models in stroke research.
INTRODUCTION The progress of effective therapies for stroke has become a challenging task for both researchers and clinicians. Some pitfalls in clinical trials might have their origins in the pre-clinical experimental ischaemic models for the evaluation of potential neuro-protective agents. METHODS We aim to standardise the methods for the development of stroke animal models throughout Spain,...
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Cover: A simplifi ed illustration of the middle cerebral artery, including its origin and branches. Made by the author. Published articles and fi gures have been reprinted with permission from the respective copyright holders.
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مقاله از نوع نامه به سردبیر است و نامه به سردبیرها فاقد چکیده هستند.
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Background and Purpose—Heparin and heparinoids have long been proposed for stroke treatment. This study investigates the effect of enoxaparin (Lovenox, Clexane), a low-molecular-weight heparin, on functional outcome (neuroscore) and lesion size in stroke models with reversible and irreversible cerebral ischemia using middle cerebral artery occlusion (MCAO) in the rat. Methods—Ischemia was induc...
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Background and Purpose: Diflusion magnetic resonance imaging (MRI) can quantitatively detect focal ischemic injury within minutes of onset, and perfusion MRI can evaluate the brain's microcirculation. N-Methyl-D-aspartate (NMDA) antagonists and reperfusion can reduce lesion size in stroke models. We used diffusion and perfusion MRI to evaluate the in vivo effects of a noncompetitive NMDA antago...
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ژورنال
عنوان ژورنال: Translational Stroke Research
سال: 2016
ISSN: 1868-4483,1868-601X
DOI: 10.1007/s12975-016-0491-5